Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
21 results
Journal of the American Heart Association, Volume 13, Issue 3, 31 5 2024, Pages e033122 Noninvasive Advanced Cardiovascular Magnetic Resonance-Derived Fontan Hemodynamics Are Associated With Reduced Kidney Function But Not Albuminuria. Van den Eynde J, Westenberg JJM, Hazekamp MG, Lamb HJ, Jongbloed MRM, Wentzel JJ, Kenjeres S, Dekkers IA, Van De Bruaene A, Rijnberg FM, Roest AAW
Background: Kidney disease is the most important predictor of death in patients with a Fontan circulation, yet its clinical and hemodynamic correlates have not been well established. Methods and results: A total of 53 ambulatory patients with a Fontan circulation (median age, 16.2 years, 52.8% male patients) underwent advanced cardiovascular magnetic resonance assessment, including 4-dimensional flow imaging and computational fluid dynamics. Estimated glomerular filtration rate (eGFR) 3 mg/mmol... Abstract
Pediatric cardiology, 24 4 2023 Comparison of Four-Dimensional Flow MRI, Two-Dimensional Phase-Contrast MRI and Echocardiography in Transposition of the Great Arteries. Warmerdam EG, Westenberg JJM, Voskuil M, Rijnberg FM, Roest AAW, Lamb HJ, van Wijk B, Sieswerda GT, Doevendans PA, Ter Heide H, Krings GJ, Leiner T, Grotenhuis HB
Pulmonary artery (PA) stenosis is a common complication after the arterial switch operation (ASO) for transposition of the great arteries (TGA). Four-dimensional flow (4D flow) CMR provides the ability to quantify flow within an entire volume instead of a single plane. The aim of this study was to compare PA maximum velocities and stroke volumes between 4D flow CMR, two-dimensional phase-contrast (2D PCMR) and echocardiography. A prospective study including TGA patients after ASO was performed b... Abstract
Cited 1 times since 2022 (0.7 per year) source: EuropePMC
Journal of magnetic resonance imaging : JMRI, Volume 57, Issue 5, 9 2 2022, Pages 1320-1339 Particle Tracing Based on 4D Flow Magnetic Resonance Imaging: A Systematic Review into Methods, Applications, and Current Developments. Roos PR, Rijnberg FM, Westenberg JJM, Lamb HJ
Background: Particle tracing based on 4D Flow MRI has been applied as a quantitative and qualitative postprocessing technique to study temporally evolving blood flow patterns. Purpose: To systematically review the various methods to perform 4D Flow MRI-based particle tracing, as well as the clinical value, clinical applications, and current developments of the technique. Study type: The study type is systematic review. Subjects: Patients with cardiovascular disease (such as Marfan, Fontan, Tetra... Abstract
Cited 1 times since 2022 (0.7 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 63, Issue 1, 1 1 2022, Pages ezac522 Haemodynamic performance of 16-20-mm extracardiac Goretex conduits in adolescent Fontan patients at rest and during simulated exercise. Rijnberg FM, van 't Hul LC, Hazekamp MG, van den Boogaard PJ, Juffermans JF, Lamb HJ, Terol Espinosa de Los Monteros C, Kroft LJM, Kenjeres S, le Cessie S, Jongbloed MRM, Westenberg JJM, Roest AAW, Wentzel JJ
Objectives: To date, it is not known if 16-20-mm extracardiac conduits are outgrown during somatic growth from childhood to adolescence. This study aims to determine total cavopulmonary connection (TCPC) haemodynamics in adolescent Fontan patients at rest and during simulated exercise and to assess the relationship between conduit size and haemodynamics. Methods: Patient-specific, magnetic resonance imaging-based computational fluid dynamic models of the TCPC were performed in 51 extracardiac Fo... Abstract
Cited 1 times since 2022 (0.6 per year) source: EuropePMC
Acta paediatrica (Oslo, Norway : 1992), Volume 112, Issue 2, 17 3 2022, Pages 186-199 Somatic growth in single ventricle patients: A systematic review and meta-analysis. Van den Eynde J, Bartelse S, Rijnberg FM, Kutty S, Jongbloed MRM, de Bruin C, Hazekamp MG, Le Cessie S, Roest AAW
Aim: To map somatic growth patterns throughout Fontan palliation and summarise evidence on its key modifiers. Methods: Databases were searched for relevant articles published from January 2000 to December 2021. Height and weight z scores at each time point (birth, Glenn procedure, Fontan procedure and >5 years after Fontan completion) were pooled using a random effects meta-analysis. A random effects meta-regression model was fitted to model the trend in z scores over time. Results: Nineteen... Abstract
Cited 5 times since 2022 (2.6 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 62, Issue 1, 1 1 2022, Pages ezab478 Extracardiac conduit adequacy along the respiratory cycle in adolescent Fontan patients. Rijnberg FM, van der Woude SFS, Hazekamp MG, van den Boogaard PJ, Lamb HJ, Terol Espinosa de Los Monteros C, Kroft LJM, Kenjeres S, Karim T, Jongbloed MRM, Westenberg JJM, Wentzel JJ, Roest AAW
Objectives: Adequacy of 16-20mm extracardiac conduits for adolescent Fontan patients remains unknown. This study aims to evaluate conduit adequacy using the inferior vena cava (IVC)-conduit velocity mismatch factor along the respiratory cycle. Methods: Real-time 2D flow MRI was prospectively acquired in 50 extracardiac (16-20mm conduits) Fontan patients (mean age 16.9 ± 4.5 years) at the subhepatic IVC, conduit and superior vena cava. Hepatic venous flow was determined by subtracting IVC flow fr... Abstract
Cited 6 times since 2022 (2.8 per year) source: EuropePMC
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, Volume 24, Issue 1, 28 4 2022, Pages 21 4D flow cardiovascular magnetic resonance derived energetics in the Fontan circulation correlate with exercise capacity and CMR-derived liver fibrosis/congestion. Rijnberg FM, Westenberg JJM, van Assen HC, Juffermans JF, Kroft LJM, van den Boogaard PJ, Terol Espinosa de Los Monteros C, Warmerdam EG, Leiner T, Grotenhuis HB, Jongbloed MRM, Hazekamp MG, Roest AAW, Lamb HJ
Aim: This study explores the relationship between in vivo 4D flow cardiovascular magnetic resonance (CMR) derived blood flow energetics in the total cavopulmonary connection (TCPC), exercise capacity and CMR-derived liver fibrosis/congestion. Background: The Fontan circulation, in which both caval veins are directly connected with the pulmonary arteries (i.e. the TCPC) is the palliative approach for single ventricle patients. Blood flow efficiency in the TCPC has been associated with exercise ca... Abstract
Cited 4 times since 2021 (1.5 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 14, Issue 8, 12 2 2021, Pages e012612 Hemodynamic Consequences of an Undersized Extracardiac Conduit in an Adult Fontan Patient Revealed by 4-Dimensional Flow Magnetic Resonance Imaging. Rijnberg FM, van Assen HC, Hazekamp MG, Roest AAW, Westenberg JJM
Cited 6 times since 2021 (2.2 per year) source: EuropePMC
European heart journal open, Volume 1, Issue 2, 9 2 2021, Pages oeab018 Segmental assessment of blood flow efficiency in the total cavopulmonary connection using four-dimensional flow magnetic resonance imaging: vortical flow is associated with increased viscous energy loss rate. Rijnberg FM, Juffermans JF, Hazekamp MG, Helbing WA, Lamb HJ, Roest AAW, Westenberg JJM, van Assen HC
Aims: To study flow-related energetics in multiple anatomical segments of the total cavopulmonary connection (TCPC) in Fontan patients from four-dimensional (4D) flow magnetic resonance imaging (MRI), and to study the relationship between adverse flow patterns and segment-specific energetics. Methods and results: Twenty-six extracardiac Fontan patients underwent 4D flow MRI of the TCPC. A segmentation of the TCPC was automatically divided into five anatomical segments [conduit, superior vena cav... Abstract
Cited 11 times since 2021 (4 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 8, 5 1 2021, Pages 683849 The Influence of Respiration on Blood Flow in the Fontan Circulation: Insights for Imaging-Based Clinical Evaluation of the Total Cavopulmonary Connection. van der Woude SFS, Rijnberg FM, Hazekamp MG, Jongbloed MRM, Kenjeres S, Lamb HJ, Westenberg JJM, Roest AAW, Wentzel JJ
Congenital heart disease is the most common birth defect and functionally univentricular heart defects represent the most severe end of this spectrum. The Fontan circulation provides an unique solution for single ventricle patients, by connecting both caval veins directly to the pulmonary arteries. As a result, the pulmonary circulation in Fontan palliated patients is characterized by a passive, low-energy circulation that depends on increased systemic venous pressure to drive blood toward the l... Abstract
The Journal of thoracic and cardiovascular surgery, Volume 163, Issue 3, 18 3 2021, Pages 1166-1175 Long-term outcomes of atrioventricular septal defect and single ventricle: A multicenter study. Arrigoni SC, IJsselhof R, Postmus D, Vonk JM, François K, Bové T, Hazekamp MG, Rijnberg FM, Meyns B, van Puyvelde J, Poncelet AJ, de Beco G, van de Woestijne PC, Bogers AJJC, Schoof PH, Ebels T
Objective: The study objective was to analyze survival and incidence of Fontan completion of patients with single-ventricle and concomitant unbalanced atrioventricular septal defect. Methods: Data from 4 Dutch and 3 Belgian institutional databases were retrospectively collected. A total of 151 patients with single-ventricle atrioventricular septal defect were selected; 36 patients underwent an atrioventricular valve procedure (valve surgery group). End points were survival, incidence of Fontan c... Abstract
Cited 4 times since 2021 (1.3 per year) source: EuropePMC
Journal of the Royal Society, Interface, Volume 18, Issue 177, 7 1 2021, Pages 20201027 Non-uniform mixing of hepatic venous flow and inferior vena cava flow in the Fontan conduit. Rijnberg FM, van der Woude SFS, van Assen HC, Juffermans JF, Hazekamp MG, Jongbloed MRM, Kenjeres S, Lamb HJ, Westenberg JJM, Wentzel JJ, Roest AAW
Fontan patients require a balanced hepatic blood flow distribution (HFD) to prevent pulmonary arteriovenous malformations. Currently, HFD is quantified by tracking Fontan conduit flow, assuming hepatic venous (HV) flow to be uniformly distributed within the Fontan conduit. However, this assumption may be unvalid leading to inaccuracies in HFD quantification with potential clinical impact. The aim of this study was to (i) assess the mixing of HV flow and inferior vena caval (IVC) flow within the... Abstract
Cited 5 times since 2021 (1.6 per year) source: EuropePMC
Scientific reports, Volume 11, Issue 1, 22 4 2021, Pages 6507 Reduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway. Rijnberg FM, van Assen HC, Juffermans JF, Kroft LJM, van den Boogaard PJ, de Koning PJH, Hazekamp MG, van der Woude SFS, Warmerdam EG, Leiner T, Grotenhuis HB, Goeman JJ, Lamb HJ, Roest AAW, Westenberg JJM
Long scan times prohibit a widespread clinical applicability of 4D flow MRI in Fontan patients. As pulsatility in the Fontan pathway is minimal during the cardiac cycle, acquiring non-ECG gated 3D flow MRI may result in a reduction of scan time while accurately obtaining time-averaged clinical parameters in comparison with 2D and 4D flow MRI. Thirty-two Fontan patients prospectively underwent 2D (reference), 3D and 4D flow MRI of the Fontan pathway. Multiple clinical parameters were assessed fro... Abstract
Cited 5 times since 2019 (1.1 per year) source: EuropePMC
Interactive cardiovascular and thoracic surgery, Volume 29, Issue 3, 1 1 2019, Pages 461-468 A 45-year experience with the Fontan procedure: tachyarrhythmia, an important sign for adverse outcome. Rijnberg FM, Blom NA, Sojak V, Bruggemans EF, Kuipers IM, Rammeloo LAJ, Jongbloed MRM, Bouma BJ, Hazekamp MG
Objectives: This study aims to evaluate our 45-year experience with the Fontan procedure and to identify risk factors for late mortality and morbidity. Methods: Demographic, preoperative, perioperative and postoperative characteristics were retrospectively collected for all patients who underwent a Fontan procedure in a single centre between 1972 and 2016. Results: The study included 277 Fontan procedures (44 atriopulmonary connections, 28 Fontan-Björk, 42 lateral tunnels and 163 extracardiac co... Abstract
Cited 7 times since 2019 (1.4 per year) source: EuropePMC
European heart journal, Volume 40, Issue 26, 1 1 2019, Pages 2170 Tornado-like flow in the Fontan circulation: insights from quantification and visualization of viscous energy loss rate using 4D flow MRI. Rijnberg FM, van Assen HC, Hazekamp MG, Roest AAW
Cited 10 times since 2019 (2 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 55, Issue 6, 1 1 2019, Pages 1202-1210 Four-dimensional flow magnetic resonance imaging-derived blood flow energetics of the inferior vena cava-to-extracardiac conduit junction in Fontan patients. Rijnberg FM, Elbaz MSM, Westenberg JJM, Kamphuis VP, Helbing WA, Kroft LJ, Blom NA, Hazekamp MG, Roest AAW
Objectives: In patients with the Fontan circulation, systemic venous return flows passively towards the lungs. Because of the absence of the subpulmonary ventricle, favourable blood flow patterns with minimal energy loss are clinically relevant. The region where the inferior vena cava, the hepatic veins and the extracardiac conduit join (IVC-conduit junction) is a potential source of increased energy loss. The aim of this study was to evaluate the relationship between geometry and blood flow pat... Abstract
Cited 6 times since 2018 (1.1 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 54, Issue 3, 1 1 2018, Pages 585-592 Aortopexy for the treatment of tracheobronchomalacia in 100 children: a 10-year single-centre experience. Rijnberg FM, Butler CR, Bieli C, Kumar S, Nouraei R, Asto J, McKavanagh E, de Coppi P, Muthialu N, Elliott MJ, Hewitt RJ
Objectives: Our study describes and analyses the results from aortopexy for the treatment of airway malacia in children. Methods: Demographic data, characteristics and preoperative, operative and outcome details, including the need for reintervention, were collected for children undergoing aortopexy between 2006 and 2016. Results: One hundred patients [median age 8.2 months, interquartile range (IQR) 3.3-26.0 months] underwent aortopexy. Sixty-four (64%) patients had tracheomalacia (TM) only, 24... Abstract
World journal for pediatric & congenital heart surgery, Volume 9, Issue 6, 22 4 2018, Pages 638-644 Long-Term Outcome of Direct Relief of Subaortic Stenosis in Single Ventricle Patients. Rijnberg FM, Sojak V, Blom NA, Hazekamp MG
Background: Single ventricle patients with unrestrictive pulmonary blood flow and (potential) subaortic stenosis are challenging to manage and optimal surgical strategy is unknown. Direct relief of subaortic stenosis by enlargement of the ventricular septal defect and/or subaortic chamber has generally been replaced by a Damus-Kaye-Stansel or Norwood procedure due to concerns of iatrogenic heart block, reobstruction, or ventricular dysfunction. Studies reporting long-term outcome after the direc... Abstract
Cited 36 times since 2018 (6 per year) source: EuropePMC
Circulation, Volume 137, Issue 22, 1 1 2018, Pages 2393-2407 Energetics of Blood Flow in Cardiovascular Disease: Concept and Clinical Implications of Adverse Energetics in Patients With a Fontan Circulation. Rijnberg FM, Hazekamp MG, Wentzel JJ, de Koning PJH, Westenberg JJM, Jongbloed MRM, Blom NA, Roest AAW
Visualization and quantification of the adverse effects of distorted blood flow are important emerging fields in cardiology. Abnormal blood flow patterns can be seen in various cardiovascular diseases and are associated with increased energy loss. These adverse energetics can be measured and quantified using 3-dimensional blood flow data, derived from computational fluid dynamics and 4-dimensional flow magnetic resonance imaging, and provide new, promising hemodynamic markers. In patients with p... Abstract
Cited 2 times since 2014 (0.2 per year) source: EuropePMC
Pediatric pulmonology, Volume 50, Issue 1, 20 3 2014, Pages 79-84 The influence of stents on microbial colonization of the airway in children after slide tracheoplasty: a 14-year single-center experience. Rijnberg FM, Butler CR, Speggiorin S, Fierens A, Wallis C, Nouraei R, McLaren CA, Roebuck DJ, Hewitt R, Elliott MJ
Objectives: This study describes the microbial colonization profile of the airway in children after slide tracheoplasty (STP) with and without stents, and compares colonization to children undergoing cardiothoracic surgical procedures without airway related disease. Methods: A 14-year retrospective single case note review was performed on patients undergoing STP and stent insertion. Nose and throat (NT) and bronchoalveolar lavage (BAL) specimens were analyzed for microbial profile and expressed... Abstract